Smooth as a baby’s bottom” summarizes the popular notion of infant skin: the soft, supple, and practically flawless integument that is the unattainable objective of all cosmetic treatments. While there are undoubtedly plenty of skin maladies that affect those at the beginning of life, even for the smoothest of bottoms, there are critical differences worth thinking about, both in health and disease. Hence, diagnosing and treating skin diseases related to children requires special expertise. Pediatric dermatology is a subspecialty of dermatology that deals with the treatment of skin problems in children.